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肝癌的治疗目前尚无很有效的手段,鉴于医德和伦理的约束,利用肝癌实验性动物模型开展肝癌的实验性治疗研究日益受到重视。自1934年Yoshida首先用邻位氨基偶氮甲苯(OAAT)成功地诱发了大鼠肝细胞癌,其后40～60年代,各种化学物(二乙基亚硝胺、黄曲霉毒素B_1等)诱发的及移植性大小鼠肝癌模型不断问世。70年代后期相继出现了裸鼠人肝癌移植模型的报道。我国肝癌模型的研究在50年代后期开始,60年代陆续开展了奶油黄(DAB)、亚硝胺及黄曲霉毒素饲料的诱癌实验,1978年强家模等建立了我国第1株移植性大鼠肝癌模型,1981年汤钊猷等首先将1例人肝癌标本移植于裸鼠获得成功。目前采用多种方法制做的肝癌动物模型正广泛用于各种形式的实验研究。
At present, there is no effective method for the treatment of liver cancer. In view of the ethics and ethics constraints, the experimental treatment of liver cancer using experimental animal model of liver cancer has received more and more attention. Since 1934, Yoshida first successfully induced rat hepatocellular carcinoma with ortho-azido-toluidine (OAAT), and from the 1940s to the 1960s, various chemicals (diethylnitrosamine, aflatoxin B_1, etc.) Induced and transplanted mouse hepatoma models continue to come out. The late 1970s have been reported in nude mice liver transplantation model. The study of liver cancer model in China started in the late 1950s. In the 1960s, experiments on the carcinogenicity of butter yellow (DAB), nitrosamines and aflatoxins were successively carried out. In 1978, Mouse hepatocellular carcinoma model, in 1981 Tang Zhaotou, etc. First of all, one case of human hepatocellular carcinoma transplanted in nude mice was successful. Current animal models of liver cancer that are made using a variety of methods are widely used in various forms of experimental research.