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目的探讨心肌酶谱与D-二聚体(D-Dimer,DD)在新生儿高胆红素血症中的临床意义,探讨有效措施降低因高胆红素血症对新生儿的死亡率。方法对在我院自2011年l2月至2012年12月接受治疗的60例高胆红素血症的新生患儿资料进行回顾性分析,并将他们随机分为两组,一组为足月组,另一组为早产组。且两组患儿均次日空腹采静脉血分别进行血清胆红素、谷草转氨酶(AST)、乳酸脱氢酶(LDH),血浆DD、PT及APTT水平等。结果早产组患儿的血清胆红素、AST、LDH均高于早产组;DD水平随着日龄增长均有所降低,但早产儿降低较慢;APTT水平对于足月儿而言持续较长,而PT则无明显变化。结论新生儿高胆红素血症可以引起对患儿心肌的损害,且出生后DD水平高于正常值。但是通过观察心肌酶谱与D-二聚体生理水平并进行相应的治疗,能够较好地避免高胆红素血症对新生儿的危害。
Objective To investigate the clinical significance of myocardial enzymes and D-dimer (D-Dimer) in neonatal hyperbilirubinemia and to explore effective measures to reduce neonatal mortality due to hyperbilirubinemia. Methods The data of 60 neonates with hyperbilirubinaemia treated in our hospital from January 2011 to December 2012 were retrospectively analyzed and randomly divided into two groups, Group, another group of premature children. Serum bilirubin, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), plasma levels of DD, PT and APTT were detected in fasting venous blood on the next day in both groups. Results Serum bilirubin, AST and LDH in preterm group were higher than those in preterm group. The level of DD decreased with the increase of age, but decreased slowly in premature infants. The level of APTT was longer in term infants , While PT did not change significantly. Conclusion Neonatal hyperbilirubinemia can cause myocardial damage in children, and the level of DD after birth is higher than normal. However, through the observation of myocardial enzymes and D-dimer physiological level and the corresponding treatment, can be better to avoid hyperbilirubinemia harm to the newborn.