临床研究证实 ,糖尿病可促进动脉粥样硬化病变的发生和发展。关于糖尿病促进动脉粥样硬化的机制 ,目前认为与下列多种因素相关 :高血糖导致蛋白激酶Ｃ活化 ;山梨醇 (ｓｏｒｂｉｔｅ)途径活化 ;ＡＧＥ产生增多导致伴随胰岛素抵抗的氧化应激亢进 ;脂质代谢紊乱等。作者此前曾研讨 Clinical studies confirm that diabetes can promote the occurrence and development of atherosclerotic lesions. The mechanism by which diabetes contributes to atherosclerosis is currently thought to be linked to a number of factors: hyperglycemia leads to activation of protein kinase C; activation of the sorbite pathway; increased production of AGE leads to increased oxidative stress accompanied by insulin resistance; Metabolic disorders. The author had previously discussed