食管癌是一种常见的消化道恶性肿瘤,死亡率高达90%,占国内恶性肿瘤死亡的21%,严重威胁着人类的健康和生命。目前寻找一种与其相关的分子标志物,对于进一步了解食管癌的发生、发展、诊断、治疗及预后评估势在必行。微小RNA(micro RNA,miR-NA)广泛存在于真核生物中,是一类不翻译为蛋白的21～25个核苷酸的功能RNA分子,通过自身序列与靶 Esophageal cancer is a common gastrointestinal cancer, the mortality rate as high as 90%, accounting for 21% of domestic cancer deaths, a serious threat to human health and life. Currently looking for a molecular marker associated with it is imperative to further understand the occurrence, development, diagnosis, treatment and prognosis of esophageal cancer. MicroRNAs (miRNAs), widely found in eukaryotes, are a class of 21-25 nucleotide functional RNA molecules that are not translated into proteins and interact with target