Background Corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) was a simple and sensitive prognostic method that could reflect the perfusion status.Contemporary data on the relationship between CTFC and the prognosis for patients with ST-elevation myocardial infarction are not available.Methods Between January 2013 and December 2019,183 STEMI patients who attended in our center were retrospectively analyzed.All of the patients underwent primary percutaneous coronary intervention (PCI) and were with final TIMI grade 3 flow.Those patients were divided into high CTFC group (CTFC ≥23 frames,n=76) and low CTFC group (CTFC ＜23 frames,n=107).The primary endpoint was the incidence of major adverse cardiovascular events (MACEs) after 12 months.Univariate and multivariate cox regression analysis was performed to figure out prognostic factors.Results A total of 183 individuals were included in this study.MACE rate was significantly higher in those patients with high CTFC (32.9％ vs.15.7％,P=0.012),especially the revascularization rate (18.4％ vs.2.8％,P=0.012).Multivariate Cox regression analysis showed that CTFC was the independent predictors of worse prognosis[risk ratio (RR): 0.75,95％ confidence interval (CI) 0.67-0.82,P＜0.001].Conclusions CTFC is feasible to identify the high-risk group after primary PCI for STEMI patients.High CTFC was associated with poor short-term clinical outcome.