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本文应用胸腺免疫抑制物(PTISE)治疗小儿紫癜性肾炎24例,设对照组24例。实验组加用PTISE,余治疗方法两组相同。实验组有效率95.8％,对照组有效率87.4％。急性期免疫球蛋白两组均增高,恢复期均有下降。细胞免疫:急性期两组均下降,尤以CD3、CD8下降明显,CD4/CD8比值上升。恢复期实验组的CD3、CD4、CD8、CD4/CD8比值均接近正常,而对照组虽有上升,但未接近正常值,尤以CD8上升不明显,CD4/CD8比值仍增高,对照组与实验组比较有显著差异。两组治疗过程中发生感染次效、病情反复次数对照组均较实验组增多。说明PTISE治疗紫癜性肾炎是有效的。
In this paper, thymus immunosuppressive substances (PTISE) in the treatment of 24 children with purpura nephritis, control group of 24 cases. Experimental group with PTISE, more than the same treatment of two groups. The experimental group was 95.8%, while the control group was 87.4%. Acute immunoglobulin in both groups were increased, the recovery period decreased. Cellular immunity: Acute phase of both groups decreased, especially CD3, CD8 decreased significantly, CD4 / CD8 ratio increased. The recovery of experimental group CD3, CD4, CD8, CD4 / CD8 ratio were close to normal, while the control group increased, but not close to normal, especially in CD8 increased significantly, CD4 / CD8 ratio is still increased, the control group and experimental There were significant differences between groups. Infection of the two groups occurred during the treatment of sub-effect, the number of repeated cases of the control group were more than the experimental group. Description PTISE treatment of purpura nephritis is effective.