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目的研究草酸铂(L-OHP)与氟尿嘧啶(5-Fu)及亚叶酸钙(CF)联合应用治疗晚期胃癌的疗效和毒副反应。方法采用FOLFOX5方案,即L-OHP100mg/m2,静脉滴入2h,第1天;CF200mg/m2,静脉滴入2h,第1天、第2天;5-Fu400mg/m2,静脉注入(CF滴完后),第1天、第2天;5-Fu600mg/m2,持续静滴第1天、第2天;每2周重复,28d为一周期。2个周期化疗后进行疗效评价。结果总有效率为41.2%,毒副反应以骨髓抑制、感觉神经毒性为主,白细胞下降发生率为53.0%。神经毒性发生率32.4%,无Ⅳ度毒副反应。结论L-OHP、5-Fu、CF联合应用治疗晚期胃癌疗效肯定,毒副反应能耐受。
Objective To study the curative effect and toxicity of L-OHP in combination with 5-fluorouracil and calcium folinate in the treatment of advanced gastric cancer. Methods FOLFOX5 regimen was used, ie L-OHP100mg / m2, intravenously for 2h on day 1, CF200mg / m2 for 2h, on day 1 and 2, 5-Fu400mg / m2, Day 1, day 2; 5-Fu 600mg / m2, continuous intravenous infusion of the first day, the second day; repeat every two weeks, 28d for a cycle. After 2 cycles of chemotherapy efficacy evaluation. Results The total effective rate was 41.2%. The side effects were bone marrow suppression and sensory neurotoxicity. The incidence of leukopenia was 53.0%. The incidence of neurotoxicity 32.4%, no degree of toxicity. Conclusion L-OHP, 5-Fu, CF combined treatment of advanced gastric cancer is effective, toxic side effects can tolerate.