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吡喹酮是一种广谱抗蠕虫药,它的抗虫作用具有免疫依赖性和免疫协同性。该文概述了其免疫依赖性和免疫协同性的发现过程及有关证据,推断了其作用机制,介绍了吡喹酮与一些免疫因子抗日本血吸虫的协同作用以及吡喹酮抗虫治疗对宿主免疫功能的影响,并提出了需要继续探讨的问题。
Praziquantel is a broad-spectrum anthelmintic that has immunological dependence and immunocompromising effects against insects. This article summarizes the discovery process and related evidences of immune dependence and immune synergy, infers its mechanism of action, describes the synergistic effect of praziquantel and some immune factors against Schistosoma japonicum, and praziquantel resistance to host immunity Function, and put forward the need to continue to explore the issue.