论文部分内容阅读
本文对22例慢性病毒性心肌炎、9例急性病毒性心肌炎痊愈者和正常人进行了α-干扰素诱生能力和免疫指标的测定。检查发现慢性组的α-干扰素诱生能力和淋巴细胞PHA转化率较急性病毒性心肌炎痊愈组和正常对照组为低。而IgM和单份血清柯萨奇B1-6型病毒中和抗体效价≥1:32者较后二组为高。上述结果提示慢性病毒性心肌炎可能由于免疫异常引起病毒反复活动或持续存在所引起。故治疗方面尚应考虑提高机体的防御病毒能力,并提出若在心肌炎的急性期进行干扰素能力检测,低于正常给予干扰素或其他增加诱生干扰素能力的药物,有可能避免部分急性病毒性心肌炎患者进入慢性阶段。
In this paper, 22 cases of chronic viral myocarditis, 9 cases of acute viral myocarditis recovered and normal subjects were measured interferon-α-induced ability and immune parameters. Examination found that the chronic group of α-interferon induction and PHA conversion rate of lymphocytes compared with acute viral myocarditis recovery group and the normal control group is low. IgM and single serum Coxsackievirus B1-6 neutralizing antibody titers ≥1: 32 were higher in the latter two groups. These results suggest that chronic viral myocarditis may be due to immune abnormalities caused by repeated or persistent viral activity. Therefore, the treatment should be considered to improve the body’s ability to defend the virus, and proposed that in the acute phase of myocarditis for interferon detection, lower than normal interferon or other drugs that increase the ability to induce interferon, it is possible to avoid some of the acute virus Patients with myocarditis enter the chronic phase.