论文部分内容阅读
本研究比较了不同剂量RU486合并ONO802用于终止早孕(停经天数≤56d)的临床有效性及其副反应。从1989年5月至1991年1月,我们共接纳了99例对象(分三组,每组33例)。各组对象分别服用200mg、400mg 或600mg 的RU486,在第三天早晨阴道给药ONO802 1mg。三组治疗结果相似,其完全流产率分别为94%、100%和100%,无明显统计学差异。在200mg 组有2例(6%)为不全流产并由于流血较多施行了刮宫术,其中1例输血200ml。三纽均来继续妊娠。除轻微腹痛外,三组均无明显副反应。ONO802阴道给药后,各组胚囊排出时间为3.5h、3.2h 和3.2h,其间亦无统计学差异。但终止妊娠后阴道流血时间200mg组明显短于400mg 组和600mg 组,分别为11.5d、14.0d 和16.1d,有显著差异(P<0.01)。本文提示RU486合并ONO802用于终止早孕时,200mg 的RU486就可能足够了。
This study compared the clinical efficacy and side effects of different doses of RU486 with ONO802 for termination of early pregnancy (days of menopausal symptoms ≤ 56 days). From May 1989 to January 1991, we received a total of 99 subjects (divided into three groups, 33 in each group). Subjects in each group received RU486 200 mg, 400 mg, or 600 mg, respectively, and vaginal administration of ONO802 1 mg on the third morning. The results of three groups were similar, the complete abortion rates were 94%, 100% and 100% respectively, with no significant difference. In the 200mg group, 2 patients (6%) had incomplete abortion and performed curettage due to more bleeding, of which 1 case had a blood transfusion of 200ml. Three New Zealand are to continue pregnancy. In addition to mild abdominal pain, the three groups had no apparent side effects. ONO802 vaginal administration, the embryo sac of each group discharge time was 3.5h, 3.2h and 3.2h, during which there was no statistical difference. However, the vaginal bleeding time after termination of pregnancy was significantly shorter in the 200mg group than in the 400mg and 600mg groups (11.5d, 14.0d and 16.1d, respectively) (P <0.01). This article suggests RU486 combined with ONO802 for termination of early pregnancy, 200mg RU486 may be sufficient.