胰岛素样生长因子(IGF)对维持肿瘤的恶性表型是必需的,而且在肺癌中胰岛素样生长因子受体(IGF-IR)经常高水平表达。稳定转染表达IGF-IR基因起始300bp的反义质粒降低了多种肿瘤细胞系的肿瘤原性,并在多种动物实验模型上证明此方法可以诱导机体对已生成的未经基因修饰的肿瘤产生系统的抗肿瘤效应。本文中建立了表达反义IGF-IR的腺病毒载体系统,希望它能发展成为一种临床治疗肿瘤的方法。通 Insulin-like growth factor (IGF) is necessary to maintain the malignant phenotype of tumors, and the insulin-like growth factor receptor (IGF-IR) is often expressed at high levels in lung cancer. The stable transfection of an antisense plasmid with an initial 300 bp expression of the IGF-IR gene reduced the tumorigenicity of various tumor cell lines and demonstrated in a variety of animal experimental models that this method can induce organisms to have been generated without genetic modification. The tumor produces a system of anti-tumor effects. In this article, an adenoviral vector system expressing antisense IGF-IR was established, and it is hoped that it can develop into a clinical method for treating tumors. through