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TDM(Therapeutic Drug Monitoring,治疗药物监测)是临床药学的主要内容之一,随着医药学的飞速发展和现代化分析仪器及电子计算机的应用,TDM手段和理论也不断得到发展和提高。TDM主要是测定血液和体液中药物浓度以药物动力学理论为基础,应用电子计算机拟合各种药动学模型,求出药动学参数,制订出合理给药方案,以达到最佳治疗效果。本文就目前医院开展TDM工作应解决的几个关键性问题探讨如下。
TDM (Therapeutic Drug Monitoring, therapeutic drug monitoring) is one of the main contents of clinical pharmacy. With the rapid development of medicine and the application of modern analytical instruments and electronic computers, TDM methods and theories have been continuously developed and improved. TDM is mainly to determine the blood and body fluid drug concentration based on pharmacokinetic theory, the use of electronic computers to fit a variety of pharmacokinetic models, pharmacokinetic parameters obtained, to develop a reasonable dosing regimen in order to achieve the best therapeutic effect . This article on the current hospital to carry out TDM should address several key issues discussed below.