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目的 :分析肿瘤血管形成的参数 微血管计数与大肠癌肝转移的关系。方法 :应用鼠抗人Ⅷ因子抗体免疫组化法染色后微血管计数回顾性研究了 72例进展期大肠癌组织标本 ,其中 12例有肝转移。结果 :无肝转移的大肠癌微血管计数平均值为 31 7± 11 6 ,而发生肝转移的大肠癌微血管计数平均值为 35 9± 11 5 ,明显高于无肝转移的大肠癌 (P <0 0 1)。复发的 8例MVD值 35 2± 10 7,显著高于未复发的MVD值 31 9± 11 3(P <0 0 1)。结论 :用免疫组化印迹方法对大肠癌微血管计数显示 ,微血管计数与大肠癌肝转移及复发有明显相关性
OBJECTIVE: To analyze the relationship between parameters of tumor angiogenesis and microvessel count and liver metastasis of colorectal cancer. Methods: 72 cases of advanced colorectal cancer tissues were retrospectively studied with anti-human factor Ⅷ antibody immunohistochemical staining. Among them, 12 cases had liver metastasis. Results: The average number of microvessel counts of colorectal cancer without liver metastasis was 31 7 ± 11 6, while the average number of microvessel counts of colorectal cancer with liver metastases was 35 9 ± 11 5, which was significantly higher than that of colorectal cancer without liver metastasis (P <0 0 1). The MVD of 8 cases relapsed was 35 2 ± 10 7, which was significantly higher than that of the non-relapsed MVD 31 9 ± 11 3 (P 0 01). Conclusion: The microvessel count of colorectal cancer with immunohistochemical blotting showed that there was a significant correlation between microvessel count and liver metastasis and recurrence of colorectal cancer