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目的:探讨不同日龄新生儿凝血功能指标的差异。方法:选择2012年1月至2013年1月在我院儿科住院的早产儿110例,足月儿150例,早产儿与足月儿均按照不同日龄分为0-2d,2d-,1w-,2w-四组;入院12h检测凝血酶原时间、活化部分凝血酶原时间、纤维蛋白原、凝血酶时间,比较各组的凝血指标差异。结果:早产儿活化部分凝血酶原时间、凝血酶原时间及凝血酶时间均高于足月儿(P<0.05),纤维蛋白原低于足月儿(P<0.05);随着日龄的增长,早产儿及足月儿的活化部分凝血酶原时间、凝血酶原时间及凝血酶时间均逐渐降低(P<0.05),纤维蛋白原逐渐升高。结论:对新生儿的凝血功能指标进行动态监测,特别是早产儿,有助于提高其存活率和改善预后。
Objective: To investigate the difference of coagulation function indexes of neonates of different ages. Methods: From January 2012 to January 2013, 110 preterm infants hospitalized in pediatric department of our hospital and 150 full-term infants were enrolled. The preterm infants and term infants were divided into 0-2d, 2d-, 1w -, 2w-four groups; 12h after admission to detect prothrombin time, activation of partial prothrombin time, fibrinogen, thrombin time, compare the differences in the indicators of coagulation. Results: The partial prothrombin time, prothrombin time and thrombin time in preterm infants were higher than those in term infants (P <0.05) and fibrinogen were lower than those in term infants (P <0.05) Prolonged prothrombin time, prothrombin time and thrombin time in preterm and term infants decreased gradually (P <0.05) and fibrinogen increased gradually. Conclusion: The dynamic monitoring of neonatal coagulation function indicators, especially premature infants, help to improve their survival rate and improve prognosis.