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目的分析天台县人民医院非淋球菌性泌尿生殖道感染者支原体检出率及耐药性变异情况。方法采用支原体培养、鉴定及药敏试验。结果 2009—2012年检测疑似泌尿生殖道感染患者9 507例,支原体阳性率分别为39.43%、45.99%、50.25%和57.14%,呈逐年上升趋势(P<0.05);其中解脲脲原体(UU)检出率为26.97%~39.27%,人型支原体(MH)检出率为1.10%~2.40%,UU+MH混合检出率为11.36%~16.10%。耐药监测显示,UU对四环素类敏感性较高,对大环内酯类耐药性有所增高,对喹诺酮类敏感性最低;MH和UU+MH对原始霉素、交沙霉素、强力霉素和四环素的敏感性高且较稳定,对其他药物敏感性均不理想。结论支原体感染呈逐年上升趋势,耐药性变化明显。原始霉素、强力霉素、交沙霉素和四环素可作为天台县泌尿生殖道支原体感染治疗的首选药物。
Objective To analyze the detection rate of mycoplasma and variation of drug resistance in non-gonococcal genitourinary tract infection in Tiantai People’s Hospital. Methods Mycoplasma culture, identification and drug sensitivity test. Results Nine 507 cases of suspected genitourinary tract infections were detected in 2009-2012. The positive rates of Mycoplasma were 39.43%, 45.99%, 50.25% and 57.14% respectively, showing an increasing trend year by year (P <0.05). Among them, Ureaplasma urealyticum The detection rate of UU was 26.97% -39.27%, the detection rate of MH was 1.10% ~ 2.40%, and the detection rate of UU + MH was 11.36% ~ 16.10%. Drug resistance monitoring showed that UU had higher sensitivity to tetracyclines, higher resistance to macrolides and lower sensitivity to quinolones; MH and UU + MH had no effect on pristinamycin, josamycin, The high sensitivity and stability of mycotoxin and tetracycline are not sensitive to other drugs. Conclusion Mycoplasma infection showed an upward trend year by year, with significant changes in drug resistance. Primogenin, doxycycline, josamycin and tetracycline can be used as the treatment of genitourinary tract myopia Tiantai drug of choice.