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目的分析原发性醛固酮增多症(primary aldosteronism,PA)患者发生颈动脉粥样硬化的危险因素。方法 PA患者246例,依据超声检测结果分为颈动脉粥样硬化组106例和颈动脉正常组140例,比较2组一般资料,logistic回归分析PA患者发生颈动脉粥样硬化的危险因素。结果颈动脉粥样硬化组男性比例、年龄、收缩压、低密度脂蛋白胆固醇、醛固酮水平均高于颈动脉正常组(P<0.05);logistic回归分析显示男性(P<0.01,OR=2.13)、年龄(P<0.01,OR=3.46)、低密度脂蛋白胆固醇(P=0.04,OR=1.80)、醛固酮(P=0.02,OR=2.14)与颈动脉粥样硬化显著相关。结论男性、高龄、高醛固酮、高低密度脂蛋白胆固醇水平是PA患者发生颈动脉粥样硬化的危险因素。
Objective To analyze the risk factors of carotid atherosclerosis in patients with primary aldosteronism (PA). Methods 246 patients with PA were divided into carotid atherosclerosis group (106 cases) and carotid artery normal group (140 cases) according to the results of ultrasonic examination. The general data of two groups were compared. Logistic regression analysis was used to analyze the risk factors of carotid atherosclerosis in PA patients. Results The proportions of men, age, systolic blood pressure, low density lipoprotein cholesterol, and aldosterone in carotid atherosclerosis group were significantly higher than those in normal carotid artery group (P <0.05). Logistic regression analysis showed that male patients (P <0.01, OR = , Age (P <0.01, OR = 3.46), low density lipoprotein cholesterol (P = 0.04, OR = 1.80) and aldosterone (P = 0.02, OR = 2.14) were significantly associated with carotid atherosclerosis. Conclusions Male, advanced age, high aldosterone and high and low density lipoprotein cholesterol levels are risk factors for carotid atherosclerosis in PA patients.