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目的:探讨辛伐他汀对慢性心力衰竭(心衰)患者左室射血分数(LVEF),以及脑钠肽(BNP)及肿瘤坏死因子-α(TNF-α)、核转录因子(NF-κB)活性的影响。方法:将血脂正常的慢性收缩性心衰患者50例随机分为对照组(25例)和他汀组(25例)。2组均接受常规治疗(利尿剂、血管紧张素转化酶抑制剂、洋地黄、β受体阻滞剂),他汀组再加用辛伐他汀(20 mg/d)治疗,治疗前及治疗后12周均测LVEF,以及BNP、TNF-α、NF-κB活性。结果:BNP、TNF-α与心衰严重程度相关,治疗12周后,2组TNF-α、BNP、NFκ-B活性均下降(P<0.05),LVEF升高(P<0.05),且以他汀组变化更明显,与对照组比较差异有统计学意义(P<0.05)。结论:慢性心衰患者在接受常规治疗的同时,加用辛伐他汀治疗可明显改善慢性心衰患者的LVEF、BNP及降低TNF-α、NF-κB活性。
Objective: To investigate the effects of simvastatin on left ventricular ejection fraction (LVEF) and the levels of brain natriuretic peptide (BNP), tumor necrosis factor-α (TNF-α) and nuclear factor kappa B (NF-κB) in patients with chronic heart failure ) Activity. Methods: 50 patients with chronic dyslipidemia with normal blood lipids were randomly divided into control group (25 cases) and statin group (25 cases). Both groups received routine treatment (diuretics, ACE inhibitors, digitalis, beta blockers), statin plus simvastatin (20 mg / d), before and after treatment LVEF, BNP, TNF-α, NF-κB activity were measured at 12 weeks. Results: BNP and TNF-α correlated with the severity of heart failure. After 12 weeks of treatment, the activities of TNF-α, BNP and NFκB decreased (P <0.05) and LVEF increased (P <0.05) Statin group more obvious changes, compared with the control group, the difference was statistically significant (P <0.05). CONCLUSION: Simvastatin can significantly improve the LVEF, BNP and the activity of TNF-α and NF-κB in patients with chronic heart failure while receiving routine treatment.