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目的 观察葛根素对心房颤动患者血栓前状态的影响。方法 随机将 4 2例心房颤动患者分为葛根素组和阿司匹林组。另选 2 1例体检健康者作为正常对照组。在常规治疗基础上 ,葛根素组加用 5 %葡萄糖注射液 +葛根素 5 0 0mg,静脉滴注 ,每日 1次 ,连续 2周 ;阿司匹林组加用阿司匹林 15 0mg ,每日 1次 ,连续口服 2周。观察治疗前后血小板活性标志物P选择素、血浆 β 血栓球蛋白和内皮功能受损标志物血浆血管性假性血友病因子 (vWF)、血管内皮受损指标内皮素 (ET 1)的变化。结果 治疗前心房颤动患者P选择素、血浆vWF、β 血栓球蛋白 (β TG)及ET 1均显著增高。经葛根素与阿司匹林治疗均可降低P选择素、血浆vWF、β TG、ET 1的水平 ,且葛根素和阿司匹林组疗效无明显差异。结论 心房颤动患者存在血小板活性增强和内皮功能受损 ,葛根素可显著改善血小板活化状态和内皮细胞功能 ,且能与阿司匹林相媲美。
Objective To observe the effect of puerarin on the prothrombotic state in patients with atrial fibrillation. Methods Forty-two patients with atrial fibrillation were randomly divided into puerarin group and aspirin group. Another 21 cases of healthy people as a normal control group. On the basis of routine treatment, puerarin group plus 5% glucose injection + Puerarin 500mg, intravenous infusion, once daily for 2 weeks; aspirin group plus aspirin 15mg, 1 day, continuous Oral for 2 weeks. Changes of P-selectin, plasma beta-thromboglobulin and vWF, endothelin (ET 1), a marker of endothelial dysfunction, were observed before and after treatment. Results The levels of P-selectin, vWF, β-TG and ET 1 were significantly increased in patients with atrial fibrillation before treatment. Puerarin and aspirin treatment can reduce P-selectin, plasma vWF, β TG, ET 1 levels, and puerarin and aspirin no significant difference in the efficacy. Conclusions Patients with atrial fibrillation have increased platelet activity and impaired endothelial function. Puerarin can significantly improve platelet activation status and endothelial cell function, and comparable with aspirin.