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裂殖子提取液已成功地作为猴和鼠的免疫原,另外,已发现与裂殖子表面组分起反应的抗体能阻碍诺氏疟原虫裂殖子侵入红细胞或在体外抑制恶性疟原虫红内期发育。这表明在抵抗疟原虫的保护性免疫中有裂殖子表面抗原的参与。作者为了解夏氏疟原虫裂殖子膜的抗原成分,通过碘标记技术,用~(125)I标记夏氏疟原虫活裂殖子表面膜蛋白及总的裂殖子蛋白,然后与正常或免疫鼠血清反应,反应前后均通过SDS-聚丙烯酰胺凝胶电泳分析。结果:
The merozoite extract has been successfully used as an immunogen for both monkey and mouse. In addition, it has been found that antibodies reactive with merozoite surface components can hinder the invasion of erythrocytes by P. norelzo merozoites or inhibit the growth of Plasmodium falciparum Internal development. This suggests the involvement of merozoite surface antigens in protective immunity against Plasmodium. In order to understand the antigenic components of merozoite membrane of Plasmodium Chlaemi, the surface membrane proteins and total merozoite proteins of live and merozoite of P. pastoris were labeled with ~ (125) I by iodine labeling technique and then compared with normal or Immunization of rat serum reaction before and after the reaction by SDS-polyacrylamide gel electrophoresis. result: