Portal hypertension,which is a common finding in children awaiting liver transplantation,is also found after transplantation.It’s reported the case of a 6-year-old girl,transplanted for biliary atresia,who had a severe obscure-overt bleeding presenting with melena.An esophagogastroduodenoscopy showed several duodenal small,bulging lesions,with some red signs.Near the lesions,a depressed area of 2cm,covered with mixed hyperemic and white mucosa,was observed.To better evaluate these lesions,we performed an endoscopic ultrasonography(EUS) that showed multiple,round hypoechoic areas 0.5-5mm in diameter,compatible with duodenal varices,and several periduodenal anechoic lesions compatible with collaterals.A consecutive computed tomography scan showed a stenosis of the portal vein anastomosis confirmed with a transhepatic portography,which was successfully treated with balloon angioplasty.No further episodes of bleeding were observed during the follow-up.This case report suggests that EUS is safe and feasible in young children when using echoendoscopes designed for use in adults.However further studies are needed to validate the employment of this technique in the management and follow-up of pediatric portal hypertension. Portal hypertension, which is a common finding in children awaiting liver transplantation, is also found after transplantation. It’s reported the case of a 6-year-old girl, transplanted for biliary atresia, who had a severe obscure-overt bleeding presenting with melena. An esophagogastroduodenoscopy showed several duodenal small, bulging lesions, with some red signs. Near the lesions, a depressed area of ​​2 cm, covered with mixed hyperemic and white mucosa, was observed. Better than these lesions, we performed an endoscopic ultrasonography (EUS) that showed multiple, round hypoechoic areas 0.5-5mm in diameter, compatible with duodenal varices, and several periduodenal anechoic lesions of the portal vein anastomosis with a transhepatic portography, which was successfully treated with balloon angioplasty. No further episodes of bleeding were observed during the follow-up. This case report suggests that EUS is safe and feasible in young children when using echoendoscopes designed for use in adults. Still other studies are needed to validate the employment of this technique in the management and follow-up of pediatric portal hypertension.