论文部分内容阅读
目的 :研究 9 (4 乙氧羰基苯氧基 ) 6 ,7 二甲氧基 1,2 ,3,4 四氢吖啶盐酸盐 (EDT)对小鼠记忆功能的影响。方法 :采用小鼠跳台法和Y 型迷宫法 ,观察EDT对小鼠学习记忆功能的影响。结果 :EDT2 .5、5、10mg·kg- 1灌胃 5d ,对东莨菪碱、亚硝酸钠和乙醇致小鼠记忆获得、巩固及再现障碍均有不同程度的改善作用。结论 :EDT可以改善小鼠的记忆功能
OBJECTIVE: To study the effect of 9 (4-ethoxycarbonylphenoxy) 6,7-dimethoxy-1,2,3,4 tetrahydroacridine hydrochloride (EDT) on the memory function in mice. Methods: By using mouse jumping method and Y-type maze method, the effects of EDT on learning and memory function in mice were observed. Results: EDT2. 5, 5 and 10 mg · kg-1 were given orally for 5 days, which could improve the memory, sclerosis and reproductive disturbance of mice induced by scopolamine, sodium nitrite and ethanol. Conclusion: EDT can improve the memory function of mice