奥美拉唑因其直接作用于分泌胃酸的质子泵 ,具有比H2 受体拮抗剂更强的抑酸作用 ,现已成为治疗胃酸相关性疾病引起的上消化道出血的主要药物[1] 。目前 ,国内已有几种奥美拉唑胶囊用于治疗。一些体外研究表明 ,此类药物在理化特性及生物利用率等方面存在明显差异[2 ,3] 。我们 Omeprazole has a more potent antacid effect than H2 receptor antagonists due to its direct effect on gastric acid-secreting proton pump, and has become the main drug for the treatment of upper gastrointestinal bleeding caused by gastric acid-related diseases [1]. Currently, several omeprazole capsules have been used in the country for treatment. Some in vitro studies have shown that there are significant differences in the physicochemical properties and bioavailability of these drugs [2,3]. we