普萘洛尔是非选择性β肾上腺素受体(AR)阻滞剂,偶然发现其治疗严重婴幼儿血管瘤(IH)效果显著。服药后短时间内即可发现肿瘤颜色变浅,几周或数月之后肿瘤消退。该文通过对增殖期和消退期血管瘤周细胞进行检测,分析周细胞在普萘洛尔诱导血管瘤消退中的作用。与膀胱平滑肌细胞相比,血管瘤周细胞高表达β2ARmRNA。此外,在15例IH标本中,β2ARmRNA的表达水平较β1AR、β3AR及α1bAR均升高。血管瘤周细胞的抑制性实验在硅 Propranolol is a nonselective β-adrenergic receptor (AR) blocker, occasionally found to have a significant effect in the treatment of severe infantile hemangiomas (IH). Shortly after taking the tumor color can be found lighter, a few weeks or months after the tumor subsided. In this paper, the pericytes of proliferating and resolving hemangiomas were detected and the role of pericytes in the regression of propranolol-induced hemangiomas was analyzed. Compared to bladder smooth muscle cells, pericytes pericytes express β2AR mRNA overexpressing. In addition, in 15 cases of IH specimens, β2AR mRNA expression levels than β1AR, β3AR and α1bAR were increased. Inhibition of hemangiopericytes in silicon