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目的:探讨肿瘤放射增敏剂在鼻咽癌放射治疗中的临床应用效果,为提高鼻咽癌患者放射疗效及生活质量提供可靠依据,保障患者生命安全。方法:对照组鼻咽癌患者直接实施放射治疗,未使用任何增敏剂;研究组鼻咽癌患者在实施放射治疗的同时应用增敏剂甘氨双唑钠。观察并记录两组患者临床疗效、放射剂使用量、毒副反应发生情况,给予统计学分析,得出结论。结果:研究组患者经放射治疗后近期总有效率高达85.29%,显著高于对照组患者近期总有效率67.65%;研究组患者毒副反应发生率为20.59%,显著低于对照组患者毒副反应发生率61.76%,P<0.05,两组患者对比结果具有统计学意义。结论:肿瘤放射增敏剂在鼻咽癌放射治疗过程中能够显著提高患者疗效,降低放射剂使用量,从而减少毒副反应发生率,增加临床治疗安全性,保障患者疗效及生活质量,值得临床推广应用。
Objective: To investigate the clinical application of radiosensitizer in radiotherapy of nasopharyngeal carcinoma (NPC) and to provide a reliable basis for improving the radiotherapy efficacy and quality of life in patients with nasopharyngeal carcinoma and to ensure the patient’s life safety. Methods: The control group of patients with nasopharyngeal carcinoma directly radiotherapy, did not use any sensitizer; study group nasopharyngeal carcinoma patients in the implementation of radiation therapy with sensitizer glycidazole sodium. Observed and recorded two groups of patients with clinical efficacy, use of radioactive agents, the occurrence of toxic reactions, to give statistical analysis, draw conclusions. Results: The total effective rate of the study group after radiotherapy was as high as 85.29%, significantly higher than the control group, the total effective rate was 67.65%. The incidence of toxic reactions in the study group was 20.59%, significantly lower than that of the control group Response rate was 61.76%, P <0.05, the two groups of patients with significant statistical significance. Conclusion: The radiosensitizer of tumor can significantly improve the curative effect of patients during radiotherapy of nasopharyngeal carcinoma and reduce the dosage of radiological agents, so as to reduce the incidence of toxic and side reactions, increase the safety of clinical treatment, and ensure the curative effect and quality of life of patients Promote the application.