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最近铁道部浦镇车辆工厂在使用二氯甲烷为主要原料的脱漆剂时发生三例急性中毒事件,其中一例入院后肝功能出现异常。为进一步了解二氯甲烷对肝脏的影响,我们进行了二氯甲烷对肝脏的毒性研究。实验材料和方法一、急性呼吸道毒性实验称取体重为18～23克健康小鼠20只,按随机分组法分成对照组和染毒组,每组动物10只。染毒组空气染毒剂量,以小鼠二氯甲烷空气染毒一个半数
Three recent acute poisoning incidents occurred in Pucheng Vehicle Factory of the Ministry of Railways when using dichloromethane as the main raw material for paint remover. One of them had abnormal liver function after admission. To further understand the impact of methylene chloride on the liver, we conducted a study of the toxicity of methylene chloride to the liver. Materials and Methods 1. Acute Respiratory Tract Toxicity Twenty healthy mice weighing 18-23 g were weighed and divided into control group and exposure group with 10 animals in each group randomly. The dose of air in the exposure group was one and a half of that of the mouse in the methylene chloride air