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目的探讨纳洛酮治疗中重度新生儿缺氧缺血性脑病(Hypoxic-ischemic encephalopatly,HIE)的临床疗效。方法按照随机数字表法将64例患儿随机分为观察组和对照组,其中对照组患儿采用常规综合治疗,而观察组患儿在常规综合治疗的基础上采用纳洛酮治疗,比较两组患儿的临床疗效和新生儿神经行为(NBNA)评分。结果观察组的总有效率明显高于对照组,差异具有统计学意义(χ~2=6.56,P<0.05);治疗后3 d、7 d对两组患者的NBNA评分比较发现,观察组的NBNA评分明显高于对照组,差异具有统计学意义(t=6.21,3.88,P<0.05)。结论纳洛酮治疗中重度新生儿缺氧缺血性脑病疗效显著,无明显不良反应,值得临床推广使用。
Objective To investigate the clinical efficacy of naloxone in the treatment of Hypoxic-ischemic encephalopatly (HIE) in moderate-severe neonates. Methods According to the random number table method, 64 children were randomly divided into observation group and control group, in which the control group of children with conventional comprehensive treatment, while the observation group on the basis of conventional comprehensive treatment with naloxone treatment, compared with two Group clinical efficacy and neonatal neurobehavioral (NBNA) score. Results The total effective rate in the observation group was significantly higher than that in the control group (χ ~ 2 = 6.56, P <0.05). The NBNA scores of the two groups at 3 and 7 days after treatment were significantly higher than those in the control group NBNA score was significantly higher than the control group, the difference was statistically significant (t = 6.21,3.88, P <0.05). Conclusion Naloxone treatment of moderate and severe neonatal hypoxic-ischemic encephalopathy significant effect, no significant adverse reactions, it is worth promoting the use of the clinic.