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目的观测下鼻甲注射地塞米松对变应性鼻炎患者的临床疗效及对患者血清IFN-γ、IL-4含量的疗效。方法随机抽取2008年9月至2011年9月来我院门诊治疗及住院治疗的患者96例为治疗组,另选同期入院体检的96例健康体检者作为对照组,观测于下鼻甲注射地塞米松对变应性鼻炎患者的临床疗效及两组血清IFN-γ、IL-4含量的变化。结果治疗后,治疗组显效59例(61.46%),有效32例(33.33%),无效5例(5.21%),总有效率94.79%。患者出现的喷涕、鼻塞、鼻痒、流清水样鼻涕、伴或不伴嗅觉减退等临床症状及体征,其评分均较治疗前明显降低(P<0.05)。治疗前治疗组的IL-4含量明显高于对照组,IFN-γ的含量明显低于对照组(P<0.01),治疗后治疗组IL-4、IFN-γ含量分别与治疗前比较,差异有统计学意义(P<0.01)。结论注射地塞米松于下鼻甲治疗变应性鼻炎有效率高,能明显改善患者的临床症状及体征,并通过调节IFN-γ、IL-6含量的变化有效阻止变态反应性炎症的发生。
Objective To observe the clinical efficacy of inferior turbinate injection of dexamethasone in patients with allergic rhinitis and its effect on serum IFN-γ and IL-4 levels. Methods A total of 96 patients from September 2008 to September 2011 in our hospital for outpatient treatment and inpatient treatment were selected as the treatment group and 96 healthy subjects in the same period were enrolled as the control group. Clinical efficacy of mitomycin in patients with allergic rhinitis and changes of serum IFN-γ and IL-4 levels in both groups. Results After treatment, 59 cases (61.46%) were effective in the treatment group, 32 cases (33.33%) were effective, 5 cases (5.21%) were ineffective, and the total effective rate was 94.79%. Patients with nasal discharge, nasal congestion, nasal itching, watery nose, with or without loss of smell and other clinical symptoms and signs, the score was significantly lower than before treatment (P <0.05). The content of IL-4 in the treatment group before treatment was significantly higher than that in the control group, and the content of IFN-γ in the treatment group was significantly lower than that in the control group (P <0.01). After treatment, the levels of IL-4 and IFN- There was statistical significance (P <0.01). Conclusion Dexamethasone in inferior turbinate injection is effective in treating allergic rhinitis. It can significantly improve the clinical symptoms and signs of patients with allergic rhinitis. It can effectively prevent the occurrence of allergic rhinitis by regulating the content of IFN-γ and IL-6.