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目的：通过肺间质性病变的动物模型，探讨在肺间质性病变中肺血管报害的不同影像学表现及其病理基础．材料和方法：应用肺间质性病变的动物模型，对其进行HRCT、MRI、DSA肺动脉造影检查和妥拉苏林试验，并和组织病理学对照。结果：HRCT表现有肺小叶间隔样结构增厚和支气管—血管束增粗及僵直、走行不规则等。MRI表现为肺血管走行、分布不自然，周围有信号异常。DSA肺动脉造影表现为肺血管纤细、缺失和呈残根状，妥拉苏林试验提示肺动脉对药物反应的顺应性降低。组织病理学表现肺血管管壁和鞘膜下结缔组织水肿、疏松、结缔组织增生和血管管腔狭窄和闭塞。结论：几种不同的影像学检查都能发现肺间质性病变所引起的肺血管的异常，但应用HRCT观察肺血管的损害、动态监测肺血管病变和肺内病变的发生、发展、和转归更为有效。
OBJECTIVE: To investigate the different imaging manifestations of pulmonary vascular lesion in pulmonary interstitial lesions and its pathological basis through an animal model of interstitial lung disease. MATERIALS AND METHODS: The animal model of pulmonary interstitial lesions was used, and HRCT, MRI, DSA pulmonary angiography and torethulin test were performed and compared with histopathology. Results: HRCT showed pulmonary lobular septal thickening and bronchial - vascular bundle thickening and stiffness, irregular walking and so on. MRI showed pulmonary vascular walking, the distribution is not natural, around the signal abnormalities. DSA pulmonary angiography showed pulmonary vascular slender, missing and was residual roots, tore sultryine test prompted the pulmonary artery to reduce the compliance of the drug response. Histopathology showed pulmonary vascular wall and subphrenic connective tissue edema, loose connective tissue hyperplasia and vascular stenosis and occlusion. CONCLUSIONS: Several different imaging examinations can detect pulmonary vascular abnormalities caused by pulmonary interstitial lesions. However, HRCT can be used to observe the damage of pulmonary vessels and dynamically monitor the occurrence, development, and transition of pulmonary vascular lesions and intrapulmonary lesions To be more effective.