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目的探讨蒿鳖养阴软坚方治疗CCl4等所致肝纤维化的作用。方法0.5 ml CCl4/100 g wt皮下注射16次(后15次注射用CCl4∶橄榄油=4∶6,V/V)辅以10%乙醇为饮料制备肝纤维化模型,成模后以蒿鳖养阴软坚方治疗,灌胃用药[24.48 g/kg(生药/体重)和8.16 g/kg,每周6 d]2个月。结果8.16 g/kg蒿鳖养阴软坚方能明显降低肝纤维化大鼠肝组织胶原蛋白含量及血清透明质酸和IV型胶原(P<0.05)。结论蒿鳖养阴软坚方具有治疗CCl4等所致肝纤维化的作用。
Objective To investigate the effect of Arteriosclerosis Yangyin Ruanjian on hepatic fibrosis induced by CCl4. METHODS: Liver fibrosis model was established by subcutaneous injection of 0.5 ml CCl4/100 g wt subcutaneously (after 15 injections with CCl4: olive oil = 4:6, V/V) supplemented with 10% ethanol. Yin Yin Ruan Jian Fang treatment, gavage medication [24.48 g/kg (crude drug/body weight) and 8.16 g/kg, 6 days per week] 2 months. RESULTS 8.16 g/kg Artemisia scutellariae Yangyin Ruanjianfang can significantly reduce liver collagen protein content and serum hyaluronic acid and type IV collagen in hepatic fibrosis rats (P<0.05). Conclusion Artemisia wolfberry Yangyin Ruanjian has the effect of treating liver fibrosis induced by CCl4.