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烦痒宁为亚甲蓝(美蓝、甲烯蓝,Methylene blue)制剂的商品名。低浓度(1～2 mg/kg,1%溶液5～10ml)的亚甲蓝可用以治疗亚硝酸盐、氯酸盐、苯胺类及硝基苯等所引起的高铁血红蛋白血症。但高浓度的亚甲蓝(5～10mg/kg)对血红蛋白起氧化作用,使之生成高铁血红蛋白,用以治疗氰化物中毒。亚甲蓝注射液局部应用有局麻作用。稷山县痔瘘医院任全保等发现亚甲蓝口服对神经性皮炎、皮肤淀粉样变、慢性湿疹、扁平苔癣等十九种皮肤搔痒性疾病有显著的疗效,因而决定对其进行全面的研究工作。本文对其进行了全面毒性实验研究,如急性毒性实验,亚急性毒性实验,慢性毒性实验及三致实验等。
It is a trade name of a methylene blue (methylene blue, Methylene blue) formulation. Low concentrations (1 to 2 mg/kg, 1% solution 5 to 10 ml) of methylene blue can be used to treat methemoglobinemia caused by nitrites, chlorates, anilines, and nitrobenzene. However, a high concentration of methylene blue (5 to 10 mg/kg) oxidizes hemoglobin to produce methemoglobin, which is used to treat cyanide poisoning. Methylene blue injection local application of local anesthetic effect. A total of 19 kinds of pruritus such as neurodermatitis, cutaneous amyloidosis, chronic eczema, and lichen planus were found to have a significant effect on the oral administration of methylene blue, and it was decided to conduct a comprehensive study on it. jobs. In this paper, we conducted a comprehensive toxicity study, such as acute toxicity test, subacute toxicity test, chronic toxicity test and three-induced test.