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目的观察慢性咽炎合剂的长期毒性反应。方法大鼠连续56 d经灌胃给予慢性咽炎合剂,给药后一半动物进行病理、血液学和血液生化学检查,另一半动物停药观察2周,进行上述同样的检查。结果大鼠毛发光泽、活动自如、外观、摄食和粪便等均未见异常,体质量增加与对照组比较无显著性差异;心、肝肾、肾上腺、脾、肺、睾丸和卵巢的脏器系数与对照组比较均无显著性差异;血液生化指标-葡萄糖(GLU)、尿素氮(BUN)、肌酐(Crea)、总胆固醇(T-CHOL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白(TP)、白蛋白(ALB)、总胆红素(T-B IL)和碱性磷酸酶(ALP)与对照组比较均无显著差异;尸检动物重要脏器未见明显病理变化。结论慢性咽炎合剂长期毒性试验未见异常反应,临床上应用本品是安全的。
Objective To observe the chronic toxicity of chronic pharyngitis mixture. METHODS: Chronic pharyngitis mixture was given to the rats on a 56-day continuous basis. Half of the animals were given pathological, hematological, and blood biochemical tests. The other half of the animals were stopped for 2 weeks and the same tests as above were performed. Results There were no abnormalities in hair luster, activity, appearance, feeding and feces. There was no significant difference in body weight between the control group and the control group. The organ coefficients of heart, liver and kidney, adrenal gland, spleen, lung, testis and ovaries There was no significant difference compared with the control group; blood biochemical indicators - GLU, BUN, Crea, T-CHOL, alanine aminotransferase (ALT), aspartate aminotransferase (AST) There was no significant difference in total protein (TP), albumin (ALB), total bilirubin (TB IL), and alkaline phosphatase (ALP) between the control group and the control group. No significant pathological changes were found in the vital organs of the animals. Conclusion There is no abnormal reaction in long-term toxicity test of chronic pharyngitis mixture. It is safe to use this product clinically.