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胃肠间质瘤(GIST)是一组起源于胃肠道间叶源性的肿瘤,其发病率低,恶性程度有时难以评估。即使完整切除GIST后,部分病人术后仍容易发生肿瘤复发或远处转移,准确的评估GIST恶性程度及预后影响因素对指导临床个体化治疗有着重要的意义。近年来,随着临床医师对其认识的不断加深,根据其预后因素制定了多种复发危险度分级标准以判断GIST预后的评估模型。GIST预后的影响因素有肿瘤部位、大小、核分裂像数、肿瘤是否破裂、基因突变类型以及肿瘤免疫组化标记物等。
Gastrointestinal stromal tumor (GIST) is a group of gastrointestinal origin derived from the tumor, the incidence is low, the degree of malignancy is sometimes difficult to assess. Even after complete resection of GIST, some patients are still prone to tumor recurrence or distant metastasis after surgery. Accurate assessment of the degree of malignancy and prognostic factors in GIST is of great importance to guide clinical individualized treatment. In recent years, with clinicians deepening their understanding, according to their prognostic factors to develop a variety of grading risk of relapse to determine the prognosis of GIST evaluation model. The prognostic factors of GIST are tumor location, size, mitotic figures, tumor rupture, gene mutation types and tumor immunohistochemical markers.