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D 半乳糖老化小鼠是研究脑老化的常用模型,表现在皮层神经元转录水平降低,RNA及蛋白质含量下降,神经细胞数目减少,小鼠水迷宫成绩下降等,与老龄动物的表现一致[1,2 ] 。我们以往的研究发现D 半乳糖老化小鼠表现学习、记忆功能减退,海马神经元存在明显的超微结构改变,NGF和NT 3
D. Galactose-induced aging mice are a commonly used model for studying brain aging. They are characterized by reduced levels of transcription in cortical neurons, decreased levels of RNA and proteins, decreased numbers of neurons, and decline in mouse water maze performance, consistent with the performance of older animals [1]. ,2 ] . Our previous studies found that D-galactosylated mice exhibited learning and memory dysfunction, and there were obvious ultrastructural changes in hippocampal neurons, NGF and NT 3