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[目的]探讨介入热灌注化疗栓塞对肝癌患者血管内皮生长因子(VEGF)的影响。[方法]采用ELISA方法检测60例原发性肝癌患者(介入热疗组30例和常规介入组30例)治疗前后VEGF的变化,并对两组数据进行对比分析。[结果]治疗前介入热疗组血清VEGF中位值为256.42pg/ml,常规介入组为255.16pg/ml;治疗后1周介入热疗组为179.37pg/ml,较前下降;常规介入组343.58pg/ml,较治疗前升高,两组比较均有显著性差异(P<0.05)。介入热疗组2年生存率(70%)明显高于常规介入组(50%)。[结论]介入热灌注化疗栓塞可抑制VEGF的产生,对减少肿瘤新生血管的形成、防止或降低肿瘤的复发起到积极的作用,其疗效优于常规介入疗法,是治疗中晚期肝癌的一种安全有效的方法。
[Objective] To investigate the effects of chemotherapy-assisted embolization on vascular endothelial growth factor (VEGF) in patients with hepatocellular carcinoma. [Methods] The changes of VEGF in 60 cases of primary hepatocellular carcinoma (30 cases in intervention hyperthermia group and 30 cases in routine intervention group) before and after treatment were detected by ELISA. The data of two groups were compared and analyzed. [Results] The median of serum VEGF before interventional hyperthermia group was 256.42pg / ml, the normal intervention group was 255.16pg / ml; The interventional hyperthermia group was 179.37pg / ml 1 week after treatment, 343.58pg / ml, which was significantly higher than that before treatment (P <0.05). The 2-year survival rate (70%) in interventional hyperthermia group was significantly higher than that in routine intervention group (50%). [Conclusion] Interventional chemotherapy with thermal embolization can inhibit the production of VEGF and play a positive role in reducing the formation of neovascularization and preventing or reducing the recurrence of tumor. The curative effect is superior to conventional interventional therapy and is a kind of treatment for advanced hepatocellular carcinoma Safe and effective method.