文献报道血小板减少患者和实验性血小板减少动物的血清中存在能诱导巨核细胞及其前体细胞增殖和分化的血小板生成刺激因子(TSF)。但 TSF 的纯化尚未解决,其理化和生物学特性也有待进一步研究。本文对再障患者尿液提取物刺激巨核细胞集落形成的活性进行了观察,以了解其作为 TSF 纯化和特性研究的来源的可能性。 It has been reported in the literature that there is a platelet-forming stimulating factor (TSF) that can induce the proliferation and differentiation of megakaryocytes and their precursor cells in the serum of thrombocytopenic patients and experimental thrombocytopenic animals. However, the purification of TSF has not yet been solved, and its physicochemical and biological properties have yet to be further studied. This article reviews the activity of urine extract-stimulated megakaryocyte colony formation in patients with aplastic anemia to understand their potential as a source of TSF purification and characterization.