1980年,美国食品和药品管理局告诫妊娠妇女应限制咖啡的摄入,这个劝告是基于高剂量的咖啡因在几种动物实验中显示致畸作用提出来的。此后又进行了大量的流行病学调查。本文是由国际癌症研究机构和巴西Pelotas综合大学的研究工作者撰写的,报道了有关饮用咖啡可能造成对生殖危害的人类研究。 1981年,报道了三例缺指畸形病例(其中一例严重的肢畸形),三例均是在怀孕期间饮用大量咖啡的妇女所生的婴儿。由于在咖啡因对动物致畸性实验中也观察到了缺指畸形,这些病例引起了人们的注意。然 In 1980, the U.S. Food and Drug Administration cautioned pregnant women to limit coffee intake based on the teratogenic effects of high doses of caffeine in several animal experiments. Since then a large number of epidemiological investigations. This article was written by researchers from the International Agency for Research on Cancer and the Universitat de Pelotas in Brazil and reports on human studies that may cause reproductive harm in coffee drinking. In 1981, three cases of absence of deformity (one in severe limb deformity) were reported, and three were infants born to women who consumed large amounts of coffee during pregnancy. These cases have aroused people’s attention due to the lack of deformity also observed in teratogenicity experiments with caffeine in animals. Of course