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目的:了解某三甲医院药品不良反应(ADR)发生的特点,促进合理用药。方法:对某三甲医院2009年7月～2011年6月收集到的615例ADR报告进行回顾性调查。结果:>60岁人群发生ADR的比例最高,有160例(26.02%);静脉滴注引起的ADR有516例(83.90%);ADR主要累及的器官为皮肤及其附件,有285例(43.91%);严重ADR 23例,其中以发生过敏性休克为主,有13例;引起ADR的药品有16类171种,抗菌药居首位,有346例(44.88%),抗菌药中以喹诺酮类药物居首位,有81例(23.41%)。结论:加强合理用药教育和对ADR的监测,可减少和避免ADR的发生。
Objective: To understand the characteristics of adverse drug reaction (ADR) in a top three hospital and promote rational drug use. Methods: A retrospective survey of 615 ADR cases collected in a top three hospital from July 2009 to June 2011 was conducted. RESULTS: ADR was highest in 60-year-olds (160 cases, 26.02%), 516 cases (83.90%) were caused by intravenous drip, and 285 cases (43.91%) were involved in skin and appendages, %); Severe ADR in 23 cases, of which anaphylactic shock occurred in 13 cases; ADR caused by drugs in 16 categories of 171 kinds of antibacterials in the first place, 346 cases (44.88%), quinolone antibacterial drugs Class drugs ranked first, 81 cases (23.41%). Conclusion: To strengthen the rational use of drug education and ADR monitoring can reduce and avoid the occurrence of ADR.