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作者采用葡萄球菌A蛋白免疫调节法(SPAI)治疗9例难治性免疫性血小板减少性紫癜(ITP)和1例慢性淋巴细胞白血病相关的免疫性血小板减少.均系与人类免疫缺陷病毒感染无关的ITP.血小板数(plt)均低于50×10~9/L.原先已经多种其它治疗失败,包括强的松(10例),脾切除(5例)、环磷酰胺(4例)、瘤可宁(1例)、大剂量丙种球蛋白(3例)、长春新碱(3例)、秋水仙碱(2例)和炔羟雄烯异恶唑(2例).方法:全部患者采用葡萄球菌A蛋白硅酸基质柱(PROSORBA柱)治疗,含提纯的葡萄球菌A蛋白200mg.8例使用血浆分离器作连续治疗,2例因
The authors used the staphylococcal protein A immunomodulatory approach (SPAI) to treat 9 cases of refractory immune thrombocytopenic purpura (ITP) and 1 case of chronic lymphocytic leukemia-associated immune thrombocytopenia, all of which were unrelated to human immunodeficiency virus infection Of the platelet count (plt) were less than 50 × 10 ~ 9 / L. Had a variety of other treatment failed, including prednisone (10 cases), splenectomy (5 cases), cyclophosphamide (4 cases) (1 case), high dose gamma globulin (3 cases), vincristine (3 cases), colchicine (2 cases) and alkyne androstane isoxazole (2 cases) .Methods: Patients were treated with staphylococcal protein A silicic acid matrix column (PROSORBA column), including 200 mg of purified staphylococcal protein A