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为了观察脐血IgE含量、不同年龄小儿PPD皮试反应与小儿常见过敏性疾病的关系 ,探讨Th1、Th2应答失常与过敏性疾病的关联 ,进一步了解过敏性疾病的免疫发病机理 ,采用ELISA法检测204例脐血血清IgE水平 ,随访2岁龄幼儿湿疹、过敏性鼻炎、哮喘性支气管炎的发生情况 ,同时调查2岁龄幼儿和7岁龄小学生PPD皮试反应与常见过敏性疾病发生情况。结果表明 :①脐血IgE增高小儿有过敏性鼻炎、哮喘性支气管炎高发倾向。②2岁龄幼儿过敏性鼻炎、哮喘性支气管炎总的人次以PPD( -)组为多 ;有家族过敏史、反复呼吸道感染的PPD( -)年长儿患过敏性疾病机率高于PPD(+)者。提示 :脐血IgE、PPD皮试反应可做为预测小儿过敏性疾病发生的简便指标
In order to observe the IgE levels in cord blood and the relationship between PPD skin test and common allergic diseases in children at different ages, to explore the association between Th1 and Th2 response disorders and allergic diseases, to further understand the immune pathogenesis of allergic diseases and to detect by ELISA 204 cases of umbilical cord serum IgE levels were followed up 2-year-old children with eczema, allergic rhinitis, asthmatic bronchitis incidence, while 2-year-old children and 7-year-old primary PPD skin test responses and common allergic diseases. The results showed that: ① Cord blood IgE increased in children with allergic rhinitis, asthmatic bronchitis high tendency. ② The total number of children with allergic rhinitis and asthmatic bronchitis in 2-year-old children was more in the PPD (-) group; the incidence of allergic diseases in PPD (-) elderly children with family history of allergies and repeated respiratory infections was higher than that in PPD )By. Tip: umbilical cord blood IgE, PPD skin test reaction can be used as a simple indicator of predicting the occurrence of allergic diseases in children