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目的 探讨 1,6 二磷酸果糖 (FDP)对急性心肌梗死 (AMI)者心肌再灌注的心肌保护作用。方法 2 6 4例急性ST段抬高性心肌梗死 (STEMI)患者随机分为FDP组 (135例 )与对照组 (12 9例 ) ,FDP组于再灌注治疗前给予FDP 10g(10 0ml)静脉滴注 ,观察再灌注后早期ST段恢复幅度、T波倒置情况及住院期间重要心脏事件。结果 FDP组较对照组术后 1hST段恢复幅度大 (P <0 .0 5 ) ,T波倒置更早 (P <0 .0 5 ) ;FDP组住院期间主要非致死性心脏事件发生率明显低于对照组 (P <0 .0 5 )。ST段恢复幅度与T波倒置时间与住院期间非致死性心脏事件及死亡率密切相关。结论 FDP应用于STEMI再灌注治疗早期 ,有助于抬高ST段的恢复及T波早期倒置 ,改善近期临床。FDP可能是通过再灌注治疗期的能量调节减轻再灌注损伤 ,改善心肌灌注。
Objective To investigate the myocardial protective effect of fructose 1,6 diphosphate (FDP) on myocardial reperfusion in acute myocardial infarction (AMI). Methods Twenty-four patients with acute ST-segment elevation myocardial infarction (STEMI) were randomly divided into FDP group (n = 135) and control group (n = 129). FDP group was given 10 g Instillation was performed to observe the recovery of early ST segment, the T wave inversion and the important cardiac events during hospitalization after reperfusion. Results Compared with the control group, the recovery rate of FDP group was higher (P <0.05) and the T wave inversion earlier (P <0.05). The incidence of major non-fatal cardiac events in FDP group during hospitalization was significantly lower In the control group (P <0.05). The magnitude of ST segment recovery is closely related to the T wave inversion time and nonfatal cardiac events and mortality during hospitalization. Conclusions FDP can be used in the early stage of STEMI reperfusion, which can help improve the recovery of ST segment and early inversion of T wave, and improve the clinical application in the near future. FDP may reduce the reperfusion injury and improve myocardial perfusion through the energy regulation of reperfusion period.