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目的探讨吡喹酮规范与安全性应用模式的血防效果。方法在血吸虫病流行区选择3个流行村,采用规范性与安全性的化疗对策,每年选择恰当的治疗时间,因病施药,对不同的人群给予不同的化疗方案。结果规范性与安全性的化疗措施在3个试点村实施3年后,化疗覆盖率由试点前的77.45%上升到99.79%,居民感染率由试点前的3.16%下降至2.08%,吡喹酮的不良反应发生率由10.65%降至0.63%。结论在血吸虫病流行区规范性与安全性使用吡喹酮,有利于控制传染源,也是提高化疗质量、化疗覆盖率,降低居民感染率和吡喹酮的不良反应发生率的新举措。
Objective To explore the blood-armor effect of praziquantel’s standard and safety mode of application. Methods Three endemic villages were selected in the endemic area of schistosomiasis. By adopting normative and safe chemotherapy strategies, the appropriate treatment time was selected each year. Different chemotherapeutic regimens were given to different populations due to the disease. Results Normative and Safe Chemotherapy Measures After three years of implementation in three pilot villages, the coverage rate of chemotherapy increased from 77.45% before the trial to 99.79%, and the infection rate of residents dropped from 3.16% before the trial to 2.08%. Praziquantel The incidence of adverse reactions decreased from 10.65% to 0.63%. Conclusions The standard and safety of praziquantel in the endemic area of schistosomiasis is favorable for controlling the source of infection. It is also a new measure to improve the quality of chemotherapy, the coverage of chemotherapy, reduce the infection rate of residents and the incidence of adverse reactions of praziquantel.