目的探讨雷帕霉素药物涂层不同支架治疗真性冠状动脉分叉病变对患者血清脂联素、GDF-15和Cys-C水平的影响。方法按照治疗方法不同将研究对象分为双支架治疗组(n=110)与单支架治疗组(n=110),2组支架均进行雷帕霉素涂抹。另选取来本院体检的100例健康者为对照组,分别检测对照组和双支架治疗组、单支架治疗组患者治疗前、治疗后3个月、6个月血清脂联素、GDF-15及Cys-C水平。结果治疗前双支架治疗组、单支架治疗组患者血清脂联素水平明显低于对照组,血清GDF-15和Cys-C水平明显高于对照组,差异均有统计学意义(P<0.05)。双支架治疗组患者治疗3个月、6个月后血清脂联素水平明显高于单支架治疗组,血清GDF-15和Cys-C水平明显低于单支架治疗组,差异均有统计学意义(P<0.05)。结论雷帕霉素药物涂层双支架治疗真性冠状动脉分叉病变能够更有效调节患者血清脂联素、GDF-15和Cys-C水平,促进患者病情改善,具有较高的临床推广价值。 Objective To investigate the effects of rapamycin coated with different stents on serum levels of adiponectin, GDF-15 and Cys-C in patients with true coronary bifurcation. Methods According to the different treatment methods, the subjects were divided into two groups (n = 110) and single stent group (n = 110). The two groups were treated with rapamycin. Another 100 healthy people who were selected for physical examination in this hospital were selected as the control group. Serum levels of adiponectin, GDF-15, and adiponectin were measured before treatment, 3 months and 6 months after treatment in the control group and the double stent group, And Cys-C levels. Results Serum levels of adiponectin in patients with double-stent and single-stent treatment before treatment were significantly lower than those in control group, serum GDF-15 and Cys-C levels were significantly higher than those in control group (P <0.05) . Patients in the double-stent group were treated for 3 months, and serum adiponectin levels were significantly higher after 6 months than those in the single-stent group. The serum GDF-15 and Cys-C levels were significantly lower than those in the single-stent group (P <0.05). Conclusion Rapamycin-coated double stent can improve the serum adiponectin, GDF-15 and Cys-C levels in patients with true coronary bifurcation and promote the improvement of patients’ condition, which has a high clinical value.