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纤维结合蛋白(fibronectin.FN)是广泛存在于机体组织中的重要糖蛋白,它可以与纤维原、纤维蛋白原、肝素及硫酸肝素和胶原相结合,也可以通过位于细胞表面的 FN 受体与细胞和血小板等相结合。由于 FN 具有上述功能,它在伤口的修复和愈合过程中担着十分重要的作用:1)作为趋化因子(chemotaxis)诱导外周血中的单核细胞及其它吞噬细胞、上皮细胞、成纤维细胞向伤口处运动。2)作为一种非特异调理素(opsone)调动吞噬系统清除病菌及组织碎片、净化伤口。3)作为细胞运动的基质。4)作为基质形成的基础。5)作为生长因子,具有强烈的促细胞生长活性。
Fibronectin (FN) is an important glycoprotein widely found in body tissues. It can be combined with fibrinogen, fibrinogen, heparin and heparin sulfate and collagen, and can also be located on the surface of cells with FN receptors and Cells and platelets are combined. Since FN has the above functions, it plays a very important role in wound healing and healing: 1) As a chemotaxis induces monocytes and other phagocytic cells, epithelial cells, fibroblasts in peripheral blood Move to the wound. 2) As a non-opsone modulates the phagocytosis system to remove pathogens and tissue debris and purify wounds. 3) As a matrix for cell movement. 4) As the basis for matrix formation. 5) As a growth factor, it has a strong cell growth promoting activity.