[Objective] The aim of this study is to provide theoretical basis for immunizing waterfowls (duck and goose) with the inactivated oil emulsion binary vaccine against Newcastle Disease (ND) and Fowl Cholera (FC). [Method] Bacterial liquid from solid culture media inoculated avian Pasteurella multocida (APM) type A and allantoic fluid from embryonic eggs infected with Newcastle Disease Virus (NDV) attenuated strain La Scta were mixed and inactivated by formalin to prepare 5 batches of inactivated oil emulsion binary vaccine, which were then used for the safety and immune efficacy test on duck and goose. [Result] Immunized ducks and geese didnt performed any adverse reactions in the safety test of the 5 hatches of vaccine; the immune efficacy test showed that ND-HI antibody titers of ducks and geese were no less than 4 log, three weeks after inoculation, and the protection rates against NDV and APM were 100% and 66.7% -83.3%, respectively. [Conclusion] The binary vaccine against ND and FC is safe and reliable for duck and goose, and can provide them with sufficient immunity protection against ND and FC.