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目的探索重症急性呼吸道综合征患者免疫功能的变化。方法应用流式细胞仪对我院确诊的58例重症急性呼吸综合征患者外周血淋巴细胞亚群进行测定。结果重症急性呼吸综合征患者白细胞总数正常或降低,淋巴细胞的绝对数降低,CD3(T淋巴细胞)和CD4(辅助性T淋巴细胞)比正常对照组低,在不同病程的3组重症急性呼吸综合征患者中,1周内和1～3周内患者的CD3和CD4比3周后明显降低,发病后的3周逐渐恢复。结论重症急性呼吸综合征患者淋巴细胞功能降低,表现为淋巴细胞绝对数降低,T淋巴细胞总数、辅助性T淋巴细胞的降低。随着病情好转,淋巴细胞绝对数、T淋巴细胞总数和辅助性T淋巴细胞逐渐增加。
Objective To explore the changes of immune function in patients with severe acute respiratory syndrome. Methods The peripheral blood lymphocyte subsets of 58 patients with severe acute respiratory syndrome diagnosed in our hospital were determined by flow cytometry. Results The total number of white blood cells in patients with severe acute respiratory syndrome was normal or decreased, the absolute number of lymphocytes was decreased, CD3 (T lymphocyte) and CD4 (helper T lymphocyte) were lower than those in normal control group. In 3 groups of severe acute respiratory diseases Among the patients with syndromes, CD3 and CD4 in patients within 1 week and within 1 to 3 weeks were significantly lower than those after 3 weeks, and recovered gradually after 3 weeks. Conclusion The patients with severe acute respiratory syndrome have decreased lymphocyte function, which is characterized by the decrease of the absolute number of lymphocytes, the total number of T lymphocytes and the decrease of helper T lymphocytes. As the condition improved, the absolute number of lymphocytes, T lymphocytes and T-helper cells increased the total number of cells.