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重症肌无力(MG)是一种主要累及神经肌肉接头突触后膜乙酰胆碱受体(acetylcholine receptor,AChR)的自身免疫性疾病。近来研究发现肌肉特异性酪氨酸激酶(muscle-specific kinase,MuSK)抗体(MuSK Ab)与MG发病机制有关。MuSK Ab阳性MG临床表现和治疗与血清AChR(+)MG存在明显不同。MuSK Ab阳性MG病情重,容易引起漏诊和误诊。
Myasthenia Gravis (MG) is an autoimmune disease that mainly affects the postsynaptic acetylcholine receptor (AChR) of the neuromuscular junction. Recent studies have found that the muscle-specific kinase (MuSK) antibody (MuSK Ab) is involved in the pathogenesis of MG. The clinical manifestations and treatment of MuSK-Ab positive MG are significantly different from those of serum AChR (+) MG. MuSK Ab positive MG severe illness, easily lead to missed diagnosis and misdiagnosis.