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目的:探讨森林脑炎(TBE)患者中血清及脑脊液(CSF)中神经元特异性烯醇化酶(NSE)水平变化及临床意义。方法:采用电化学发光法检测35例TBE患者中脑脊液、血清中NSE水平含量为观察组,并同时为CSF中白细胞计数,对照组为同期蜱叮咬并未发生蜱传疾病病患22例。结果。TBE患者脑脊液、血清中NSE水平含量分别是22.30±6.02 ng/ml和16.63±4.36 ng/ml,明显高于对照组的8.36±6.30 ng/ml和5.34±2.46 ng/ml,两者有显著差异,P均<0.01,且TBE脑脊液与血清中NSE浓度呈正性相关(r=0.85,P<0.01)。在TBE脑脊液中NSE升高阳性率与WBC升高阳性率分别是71.41%和48.57%,两者具有显著差异,P<0.05。结论:森林脑炎患者脑脊液、血清中NSE水平明显增高,有助于早期诊断蜱传疾病中森林脑炎、预后及病程严重程度研究。特别是蜱叮咬患者中,WBC正常,测定CSF中NSE的水平含量有助于诊断森林脑炎。
Objective: To investigate the changes and clinical significance of neuron-specific enolase (NSE) in serum and cerebrospinal fluid (CSF) of patients with forest encephalitis (TBE). Methods: Cerebrospinal fluid (CSF) was detected by electrochemiluminescence in 35 TBE patients. The level of NSE in serum was observed in the observation group and the number of leukocytes in the CSF was also measured. In the control group, 22 cases of tick-borne diseases did not occur. result. The levels of NSE in cerebrospinal fluid and serum of TBE patients were 22.30 ± 6.02 ng / ml and 16.63 ± 4.36 ng / ml, respectively, which were significantly higher than those of control group (8.36 ± 6.30 ng / ml and 5.34 ± 2.46 ng / ml) , P <0.01, respectively, and there was a positive correlation between TBE CSF and NSE in serum (r = 0.85, P <0.01). The positive rates of NSE positive and WBC positive in TBE cerebrospinal fluid were 71.41% and 48.57%, respectively, with significant difference (P <0.05). Conclusion: The levels of NSE in cerebrospinal fluid (CSF) and serum of patients with encephalitis are significantly higher than those in other encephalitis patients. It is helpful for the early diagnosis of tick-borne diseases in encephalitis, prognosis and severity of disease. In particular, tick-bite patients, WBC normal, the determination of CSF levels of NSE contribute to the diagnosis of forest encephalitis.