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目的 :探讨维生素D水平与孤独症谱系障碍(Autism spectrum disorder,ASD)ASD的相关性。方法 :采用高效液相色谱-串联质谱法对225例新诊断的ASD患者和275例健康人群进行血清25-羟基维生素D(25(OH)D)检测对照,比较两组的维生素D摄入状况和ASD患者血清25(OH)D水平与ABC、CARS分值的相关性。根据家属意愿,对其中40例有维生素D不足或缺乏的ASD患者给予补充维生素D治疗。治疗3个月后二次行ABC、CARS评估及血清25(OH)D检测。结果:1.ASD患者血清25(OH)D水平明显低于健康对照组,维生素D不足和缺乏率明显高于健康对照组。2.早期治疗组ASD患者维生素D治疗前后ABC总分差值明显大于晚期治疗组ASD患者。结论 :ASD患者血清25(OH)D水平明显低于健康对照组,给予补充维生素D治疗后,早期维生素D的治疗效果优于晚期治疗。
Objective: To investigate the correlation between vitamin D levels and autism spectrum disorder (ASD) ASD. Methods: Serum 25-hydroxyvitamin D (25 (OH) D) was detected in 225 newly diagnosed ASD patients and 275 healthy subjects by HPLC-tandem mass spectrometry. The intake of vitamin D And serum 25 (OH) D levels in ASD patients with ABC, CARS scores. According to the wishes of their families, 40 cases of vitamin D deficiency or lack of ASD patients given vitamin D treatment. Three months after treatment, ABC, CARS and serum 25 (OH) D tests were performed twice. Serum 25 (OH) D levels in patients with ASD were significantly lower than those in healthy controls, and vitamin D deficiency and deficiency rates were significantly higher than those in healthy controls. Early treatment group ASD patients before and after vitamin D treatment of ABC total score was significantly greater than the late treatment group ASD patients. CONCLUSIONS: Serum 25 (OH) D levels in patients with ASD are significantly lower than those in healthy controls. Treatment with vitamin D supplementation is superior to early treatment with vitamin D in patients with ASD.