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用乳液固化方法制备了１２５Ｉ－牛血清白蛋白－黄芪多糖毫微粒，透射电子显微镜测得粒径为（１６８±６２）ｎｍ，小鼠口服毫微粒（１４８×１０８Ｂｑ／只）后，主要分布在肝、脾、肺中，而心、脑组织中有少量分布。微观放射自显影实验结果表明，毫微粒分布在肝脏的Ｋｕｆｅｒｓ细胞和肝实质细胞中，以及在肺和脾脏的吞噬细胞中。实验数据用３Ｐ８７程序处理，按血管外给药开放二室模型计算得代谢动力参数，Ｔｍａｘ为２．１１ｈ，Ｃｍａｘ为２．４３×１０７Ｂｑ，ｔ１／２为９．３３ｈ，曲线下面积为３．７×１０９Ｂｑ。
The 125I-BSA-APS nanoparticles were prepared by the emulsion-solidification method. The diameter of the nanoparticles was (168 ± 62) nm after transmission electron microscopy. After the mice were orally administered with nanoparticles (148 × 108Bq / mouse) Liver, spleen, lung, and heart, brain tissue in a small amount of distribution. Micro-autoradiography experiments showed that nanoparticles were distributed in the liver Kufers cells and hepatic parenchymal cells, as well as in the lung and spleen of phagocytes. The experimental data were processed by 3P87 program. The calculated pharmacokinetic parameters were as follows: Tmax was 2.11h, Cmax was 2.43 × 107Bq and t1 / 2 was 9.33h. The area under the curve was 3. 7 × 109Bq.