【摘 要】
：
One of the hallmarks of the mature neurons from the central nervous system (CNS) is their inability to grow their axons after an insult. In turn, whenever a neuronal circuit is damaged, either by a neurodegenerative disease or a traumatic injury, the moto
【机 构】
：
Univ.Grenoble Alpes,Inserm,Grenoble Institut Neurosciences,Grenoble,France
论文部分内容阅读
One of the hallmarks of the mature neurons from the central nervous system (CNS) is their inability to grow their axons after an insult. In turn, whenever a neuronal circuit is damaged, either by a neurodegenerative disease or a traumatic injury, the motor and/or cognitive functions associated with it are lost permanently. Therefore, understanding the molecular and cellular barriers to CNS repair is a major challenge not only for Neurosciences but also for public health.rnRegrowing mature axons has been the limiting step in the field of CNS regeneration for many years. Indeed, for a long time, studies focused only on the inhibitory role of the environment (glial scar and myelin debris), but its manipulation resulted on moderate growth (He and Jin, 2016). Ten years ago, the discovery of the critical role of neurons themselves has been a game changer leading to extensive axonal regeneration: from the eye to the brain in the visual system (Belin et al., 2015; He and Jin, 2016). In addition, it has been shown recently that regenerating axons can be myelinated using a combination of drugs (Wang et al., 2020). This is a critical milestone to reach the functionality of the regenerating circuit.
其他文献
To the Editor,rnAnosmia, which coupled with altered or loss of taste, during the current pandemic in individuals has heralded the onset of coronavirus disease 2019 (COVID-19). The recovery from the anosmia has been seen to vary among individuals, which in
Glaucoma is a neurodegenerative chronic pathology, characterized by the loss of retinal ganglion cells (RGC), which leads to an irreversible vision field loss. The increased intraocular pressure (IOP) constitutes its main risk factor. Nowadays, the main t
During acute reperfusion,the expression profiles of long noncoding RNAs in adult rats with focal cerebral ischemia undergo broad changes.However,whether long noncoding RNAs are involved in neuroprotective effects following focal ischemic stroke in rats re
Acupuncture at acupoints Baihui(GV20)and Dazhui(GV14)has been shown to promote functional recovery after stroke.However,the contribution of the contralateral primary sensory cortex(S1)to recovery remains unclear.In this study,unilateral local ischemic inf
MicroRNAs can regulate the function of ion channels in many organs. Based on our previous study we propose that miR-142a-39, which is highly expressed in denervated skeletal muscle, might affect cell excitability through similar mechanisms. In this study,
Exploring the Alzheimer\'s disease neuroepigenome: recent advances and future trends: Alzheimer\'s disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. After decades of ongoing efforts by scientists, many hallmark
The development of amyotrophic lateral sclerosis (ALS) may be related to the abnormal alterations of multiple proteins. Our previous study revealed that the expression of phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4) was decreased in ALS. Howeve
The gastrointestinal track is inhabited by tens of trillions of microorganisms. The gut microbiota is involved in gut motility, nutrient absorption and synthesis of metabolites that influence homeostasis, metabolism and immune function. Given the influenc
Retinal ganglion cell (RGC) axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the brain. RGC axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon regen
Amyotrophic lateral sclerosis (ALS) is a highly aggressive adult-onset neurodegenerative disease caused by the progressive loss of upper and lower motor neurons. Clinically, it causes irreversible muscle atrophy and spasticity, leading to death due to res